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By Dietmar Krautwurst (eds.)

Medicinal chemistry is either technological know-how and artwork. The technology of medicinal chemistry deals mankind considered one of its top hopes for making improvements to the standard of lifestyles. The artwork of medicinal chemistry maintains to problem its practitioners with the necessity for either instinct and adventure to find new medicines. for that reason sharing the event of drug learn is uniquely invaluable to the sphere of medicinal chemistry. Drug study calls for interdisciplinary team-work on the interface among chemistry, biology and medication. for this reason, the topic-related sequence subject matters in Medicinal Chemistry covers all appropriate elements of drug learn, e.g. pathobiochemistry of ailments, identity and validation of (emerging) drug pursuits, structural biology, drugability of objectives, drug layout methods, chemogenomics, man made chemistry together with combinatorial equipment, bioorganic chemistry, usual compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions at the molecular point, structure-activity relationships, drug absorption, distribution, metabolism, removal, toxicology and pharmacogenomics. ordinarily, specified volumes are edited through renowned visitor editors.

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Nature 396(6712):683–687. 1038/25360 78. Kuner R, Kohr G, Grunewald S, Eisenhardt G, Bach A, Kornau HC (1999) Role of heteromer formation in GABAB receptor function. Science 283(5398):74–77 Taste Receptor Gene Expression Outside the Gustatory System 29 79. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1998) Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396(6712):679–682. 1038/25354 80. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors.

The rather “benign” phenotypes, observed in the various taste receptor knockout mouse models, suggest that even animals, which have maintained their full taste receptor gene repertoire in the course of evolution, can obviously compensate the acute loss of extraoral taste receptors quite well. Another issue arises from the fact that taste receptors in the oral cavity are rather low-affinity receptors devoted to detect food-derived compounds at high and nutritionally relevant concentrations. For taste receptors, expressed outside the oral cavity, the question arises whether the corresponding stimuli reach concentrations relevant to modulate the receptor’s activities.

Proc Natl Acad Sci U S A 109(8):E524–E532. 1115183109 16. Mace OJ, Affleck J, Patel N, Kellett GL (2007) Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582(Pt 1):379–392 17. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP (2007) T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 104 (38):15075–15080 18.

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