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By C. Schiepers (auth.), Christiaan Schiepers MD, PhD (eds.)

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Letal SPECT has also been ap- does not result in anesthesia of the entire hippoeamplied to frontal lobe epilepsy, demonstrating a 91 % pus in many patients (JEFFERY et al. 1991). If the amosensitivity of correctly localizing lateralized seizure barbital is not delivered to the hippocampus, falsefoei. Peri-ictal scanning in pediatric patients has negative memory lateralization may occur. Co-adbeen specifically evaluated and found to be benefieial ministration of 99mTc-HMPAO and amobarbital via the internal carotid artery can be used to assess areas (O'BRIEN et al.

1989, 1991a; GRÜNWALD et al. 1991; KRAUSZ et al. 1991; NEWTON 1992; THoMAs et al. 1992). Overall, these results demonstrate the high sensitivity in localizing seizure foei comparable to that of 18F_FDG PET (70%), but so me 24 G. Lucignani, J. J. Frost studies have shown a lower sensitivity, stimulating with 18p-PDG-PET imaging, SPECT perfusion imaging is more sensitive than MRI (CORDES et al. 1990). the use of ictal SPECT scanning. Due to the longer half-life of SPECT blood flow ra- The presence of interictal hypoperfusion is similarly diopharmaceuticals, the use of ictal and postictal more eommon in patients with T2-weighted MRI abscanning in patients with epilepsy has been explored normalities, as compared with patients with normal in recent years (Magistretti and UREN 1983; LEE et al.

Aecordingly, administration hyperperfusion that correlate with the electrical and of amobarbital via the intracarotid artery probably clinical localization. letal SPECT has also been ap- does not result in anesthesia of the entire hippoeamplied to frontal lobe epilepsy, demonstrating a 91 % pus in many patients (JEFFERY et al. 1991). If the amosensitivity of correctly localizing lateralized seizure barbital is not delivered to the hippocampus, falsefoei. Peri-ictal scanning in pediatric patients has negative memory lateralization may occur.

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